Journal: Scientific Reports
Article Title: Monitoring cerebral hemodynamic change during transcranial ultrasound stimulation using optical intrinsic signal imaging
doi: 10.1038/s41598-017-13572-0
Figure Lengend Snippet: Separation of global and local hemodynamic changes using PCA. ( a ) The averaged HbO concentration change among six animals recovered from the maximum peak of PC1 and PC2. The asterisk (*) indicates the statistically significant difference (repeated measures one-way ANOVA with Tukey-Kramer post-hoc analysis; p < 0.05) in amplitude varying by tUS parameter. Error bars indicate the standard deviation between subjects. ( b ) The average of the normalized two components of the HbO signal for three different paradigms in a representative mouse. Error bars indicate the standard deviation between paradigms. The second principal component correlates strongly with the associated HRF for the stimulation. ( c ) The corresponding images from the first (top row) and second (bottom row) principal components for each paradigm. The color bar indicates the normalized magnitude of PC coefficients. The white dots indicate the bregma.
Article Snippet: In addition, principal component analysis (PCA) (Statistics and Machine Learning Toolbox, Matlab, Mathworks Inc., USA) was applied to remove motion artefacts and decompose the signal into different sources .
Techniques: Concentration Assay, Standard Deviation